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Free Immune Checkpoint Diagram Generator

Create PD-1/PD-L1 and CTLA-4/B7 schematics with distinct inhibition and blockade views. Edit cell and molecule labels and export SVG or PNG.

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Free Immune Checkpoint Diagram Generator— templates & examples

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Free Immune Checkpoint Diagram Generator

Create PD-1/PD-L1 and CTLA-4/B7 schematics with distinct inhibition and blockade views. Edit cell and molecule labels and export SVG or PNG.

An immune checkpoint diagram shows receptor–ligand interactions that regulate immune-cell signaling, such as PD-1/PD-L1 and CTLA-4/B7. Create PD-1/PD-L1 and CTLA-4/B7 schematics with distinct inhibition and blockade views. Edit cell and molecule labels and export SVG or PNG.

Open the free tool
Immune checkpoint receptor–ligand schematic with labeled cells
  • Locate PD-1 and PD-L1
  • Explain CTLA-4 and B7
  • Distinguish inhibition from blockade
  • Edit an immunology schematic

Immune Checkpoint Diagram Generator Features

Use SciFig to work with the specific inputs, labels and exported outputs described below.

Locate PD-1 and PD-L1

Place PD-1 on the T-cell side and PD-L1 on the opposing cell in the supported interaction schematic. SciFig’s immune checkpoint diagram retains cell boundaries and receptor labels, giving the audience a spatial reference for the checkpoint interaction.

  • Identify the T-cell side
  • Locate PD-1 and PD-L1
  • Retain cell boundaries
Locate PD-1 and PD-L1

Explain CTLA-4 and B7

Switch to the CTLA-4/B7 mechanism to show a different receptor–ligand pair. The view uses its own labels and cell context rather than replacing only the title of the PD-1 panel. Keep the selected checkpoint name visible when exporting panels for a comparison.

  • Select the CTLA-4 view
  • Identify the B7 ligand
  • Keep the mechanisms distinct
Explain CTLA-4 and B7

Distinguish inhibition from blockade

Choose the inhibitory interaction or its blockade view. SciFig uses distinct connection marks for the checkpoint signal and the interruption of that interaction. This makes blockade a change in the depicted mechanism rather than an arrow that falsely labels the checkpoint itself as a stimulatory signal.

  • Show inhibitory signaling
  • Toggle the blockade view
  • Keep connection meanings explicit
Distinguish inhibition from blockade

Edit an immunology schematic

Change the scientific annotations and colors to fit the explanation, then export SVG or PNG. Save JSON settings for a later revision. The finite local tool helps build a mechanism panel while keeping receptor placement and the chosen interaction visible.

  • Edit molecular labels
  • Export vector or raster
  • Save a reusable configuration
Edit an immunology schematic

How to Create the Diagram

Follow the local controls to prepare the immune checkpoint diagram from your input.

  1. Choose the checkpoint pair

    Select PD-1/PD-L1 or CTLA-4/B7. The preview shows the chosen receptor and ligand in their cell context. Use one pair per focused explanation before assembling a comparison panel.

  2. Select interaction or blockade

    Choose whether the figure explains the inhibitory interaction or its interruption. Follow the connection marks in the preview so the annotation distinguishes a checkpoint signal from blockade of that interaction.

  3. Edit the cell and molecule labels

    Set the title and scientific annotations used in your lesson. Retain the receptor–ligand identities and cell boundaries while choosing colors that make the two sides of the interaction readable.

  4. Download the mechanism panel

    Export SVG or PNG and save JSON settings. Reopen the configuration to revise terminology or switch the supported view. Keep each panel labeled when placing several checkpoint diagrams in the same presentation.

Ways to Use the Diagram

Choose a focused figure for the question and document you are preparing.

PD-1 on a T cell interacting with PD-L1 on an opposing cell

Teach PD-1 signaling

Use the PD-1/PD-L1 panel to locate the receptor and ligand on opposing cells. The inhibitory connection provides a concrete visual reference for the checkpoint mechanism being introduced.

Explore this example
CTLA-4/B7 inhibitory interaction between labeled cells

Teach CTLA-4 interactions

Prepare a focused CTLA-4/B7 panel for a lesson on immune regulation. Keeping the receptor names in the figure helps separate this interaction from the different checkpoint pair used in a PD-1 example.

Explore this example
Blockade of the PD-1/PD-L1 interaction

Explain checkpoint blockade

Compare interaction and blockade views while preserving the same cell arrangement. The changed connection marks help the audience follow what is interrupted, without implying a clinical outcome from the schematic alone.

Explore this example
Immune checkpoint receptor–ligand schematic with labeled cells

Prepare an immunology seminar

Export a receptor–ligand panel to introduce a broader immune-regulation discussion. Labels and cell placement make the panel understandable when it appears apart from the slide’s spoken explanation.

Explore this example
Blockade of the CTLA-4/B7 checkpoint interaction

Connect activation and regulation

Pair the checkpoint panel with a T-cell activation schematic. The activation figure establishes the broader context, while the checkpoint figure focuses on a specific regulatory interaction between two cells.

Explore this example
Immune checkpoint receptor–ligand schematic with labeled cells

Share consistent mechanism figures

Save the chosen checkpoint and annotations in JSON when coordinating several presentation panels. Reopen the configuration to edit wording and export a revised version while retaining the interaction represented by the original panel.

Explore this example

How Researchers Use SciFig

I needed an immune checkpoint diagram that placed PD-1 on the T-cell side and PD-L1 on the opposing cell. I selected the inhibition preset and edited the cell labels. The SVG gave our seminar a readable receptor–ligand overview, with the inhibitory signal separated from the clinical response data shown later.

Sara Mitchell

Tumour Immunology Doctoral Researcher · University of Southampton

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